Nitric Oxide as a Mediator for Defense Responses
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چکیده
منابع مشابه
Nitric oxide as a mediator of delayed pharmacological (A receptor
Background: Nitric oxide (NO), synthesised from the inducible isoform of nitric oxide synthase (iNOS), is implicated in mediating second window of protection (SWOP)/delayed ischemic preconditioning. However the role of NO and iNOS in delayed pharmacological protection remains unclear and is the subject of this investigation. Methods: To test the hypothesis that iNOS is necessary for delayed 6 p...
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Part of the regulation of gastrointestinal (GI) smooth muscles is provided by nonadrenergic noncholinergic (NANC) nerves. Stimulation of these nerves, either by field stimulation or via neural reflex pathways, elicits hyperpolarization of postjunctional smooth muscle membranes referred to as inhibitory junction potentials and relaxation. The transmitter(s) that mediate NANC inhibitory neural tr...
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Inflammation influences the development of cancer. The nitric oxide synthase (NOS2) is induced by inflammatory cytokines, e.g., tumor necrosis factor alpha and interleukin 1beta, and produces nitric oxide (NO*), a critical mediator of the inflammatory response. Because p53 governs NO* production by transcriptionally transrepressing NOS2, we used a genetic strategy to determine whether NO* and p...
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Ultraviolet (UV) radiation is the main physiological stimulus for human skin pigmentation. Within the epidermalmelanin unit, melanocytes synthesize and transfer melanin to the surrounding keratinocytes. Keratinocytes produce paracrine factors that affect melanocyte proliferation, dendricity, and melanin synthesis. In this report, we show that normal human keratinocytes secrete nitric oxide (NO)...
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Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO*) and increased indices of NO* -dependent oxidative stress. Although NO* is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution of NO* to lung injury in several disease models. On the basis of biochemical ...
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ژورنال
عنوان ژورنال: Molecular Plant-Microbe Interactions®
سال: 2013
ISSN: 0894-0282,1943-7706
DOI: 10.1094/mpmi-09-12-0214-cr